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Leaf Pattern Design

Hormone Therapy After Cancer

An assessment, not a blanket no.

Most survivors are told hormones are permanently off the table. No assessment, no discussion of which hormone or which route. Just a closed door, and then years of sleeplessness, joint pain, brain fog and vaginal atrophy that nobody will treat.

That blanket answer traces back to a misreading of the 2002 Women's Health Initiative data. It does not reflect where the evidence sits now. Hormone replacement after breast cancer is a decision that belongs to you, made with someone who has actually read your chart.

What actually depends on what

Cancer type. Hormone receptor status. Stage and time since treatment. Which hormone is being considered, and by what route.

Bioidentical progesterone carries a meaningfully different risk profile than synthetic progestins such as medroxyprogesterone acetate. The molecular structures differ, the receptor interactions differ and the breast tissue effects differ. These are not interchangeable drugs, and the research that frightened everyone was largely done on the synthetic.

Vaginal estrogen is considered safe for many breast cancer survivors, including some on aromatase inhibitors. Systemic absorption is minimal. For genitourinary symptoms it is often the single highest-yield option available, and it is routinely withheld.

What brings people here

Hot flashes and night sweats after breast cancer. Vaginal dryness and painful sex on an aromatase inhibitor. Joint pain that started with endocrine therapy. Sleep that never recovered after treatment. Brain fog nobody will attribute to hormones. Loss of libido. Bone density loss on hormone suppression. Perimenopause and menopause in women who also have a cancer history.

What I prescribe

Bioidentical progesterone. Vaginal estrogen. Systemic estradiol where the cancer type and receptor status support it. DHEA and thyroid support where testing warrants it. Non-hormonal options when hormones are genuinely not appropriate, because that happens too.

What I will and will not tell you

I will tell you what the evidence supports for your specific situation, what is uncertain and where I would proceed cautiously. Some women, after that conversation, decide against hormones. That is a fine outcome. What I object to is the decision being made for you without anyone looking at your chart.

I will also coordinate with your oncologist. This works better when everyone is in the same conversation.

What a visit involves

Full review of pathology, receptor status, treatment history and current symptoms. Labs where they change the decision. A plan that names what we are treating and how we will know it is working.

Cost

Initial consultation is $350 for 60 minutes. Follow-ups start at $120. Visits are self-pay and I do not bill insurance.

Washington and Oregon

Prescribing is limited to patients in Washington and Oregon. Outside those states I can review your case and provide guidance.

Book a free 15-minute consult.

© 2026 Dr. Ksenia Malarkey · Seattle, WA · (206) 414-8656 · Messages only, please book online

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